Spinal cord compression by extramedullary haematopoiesis in myelofibrosis.

نویسندگان

  • D C Crawford
  • S Nightingale
  • D Bates
  • B E Tomlinson
چکیده

A 50-year-old man with a 20-year history of myelofibrosis developed mild impairment of dorsal column sensation and ataxia of gait. A myelogram and subsequent peroperative biopsy demonstrated spinal cord compression due to extramedullary haematopoiesis. There was an excellent clinical response to surgery and radiotherapy. The characteristic clinical features and the pathogenesis of this unusual complication of myelofibrosis and extramedullary haematopoiesis are discussed.

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References APPLEBY, A., BATSON, G.A., LASSMAN, L.P. & SIMPSON, C.A. (1964) Spinal cord compression by extramedullary haematopoiesis in myelosclerosis. J. Neurol. Neurosurg. Psychiat. 27, 313. ASK-UPMARK, E. (1945) Tumour-simulating intra-thoracic heterotopia of bone marrow, Acta radiol. (Stockh.), 26, 425. BRANNAN, D. (1927) Extramedullary hematopoiesis in anaemias. Bull. Johns Hopk. Hosp. 41 1...

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Spinal Cord Compression by Extramedullary Haematopoiesis in Myelosclerosis.

Spinal cord compression by extradural deposits is not uncommon in myeloma (Clarke, 1956; McKissock, Bloom, and Chynn, 1961), leukaemia (Wilhyde, Jane, and Mullan, 1963), and Hodgkin's disease (Bhagwati and McKissock, 1961). Cord compression by the malignant lymphomas is discussed by Love, Miller, and Kernohan (1954) and by Hutchinson, Leonard, Maudsley, and Yates (1958). Close, Taira, and Cleve...

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Extramedullary haematopoiesis associated with thalassaemia leading to spinal cord compression is an extremely rare event in the course of the disease. The efficacy of radiation therapy is advocated in the management of such a complication. Two patients with thalassaemia, who had presented with spinal cord compression, were successfully treated by a modest dose of local radiotherapy. In one of t...

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Spinal cord compression due to extramedullary haemopoiesis in myelofibrosis.

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عنوان ژورنال:
  • Postgraduate medical journal

دوره 60 699  شماره 

صفحات  -

تاریخ انتشار 1984